Open AccessCinoxacin: In Vitro Antibacterial Studies of a New Synthetic Organic Acid
Author(s) -
Robert M. Lumish,
Carl W. Norden
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.7.2.159
Subject(s) - nalidixic acid , serratia marcescens , agar dilution , microbiology and biotechnology , minimum inhibitory concentration , enterobacter , agar , proteus , escherichia coli , enterobacteriaceae , biology , antibacterial agent , pseudomonas aeruginosa , bacteria , serratia , pseudomonas , antibiotics , biochemistry , antibiotic resistance , genetics , gene
Cinoxacin (compound 64716) is a synthetic organic acid with antibacterial activity against most aerobic gram-negative bacilli. Minimal inhibitory concentrations of cinoxacin (agar-dilution method) were determined for 419 strains.Escherichia coli was the most susceptible group of organisms. The majority ofKlebsiella sp.,Enterobacter sp.,Proteus sp., andSerratia marcescens were inhibited by 8 μg of cinoxacin per ml.Pseudomonas aeruginosa and all gram-positive isolates tested were resistant to 64 μg or less of cinoxacin per ml. Zones of inhibition using a 30-μg disk correlated well with agar-dilution minimal inhibitory concentrations (r = −0.9). Cinoxacin was bactericidal when tested with inocula of 5 × 106 organisms per ml. Resistance to cinoxacin was readily developed in all three strains tested by serial passage on drug-containing agar. The in vitro properties of this agent were similar to those of nalidixic acid.