Isolation and Characterization of a γ-Thiochromanone-4-Thiosemicarbazone-Resistant Mutant of Vaccinia Virus | Zendy

Ehud Katz | Zendy; Eva Margalith | Zendy; Bela Winer | Zendy

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Isolation and Characterization of a γ-Thiochromanone-4-Thiosemicarbazone-Resistant Mutant of Vaccinia Virus

Author(s) -

Ehud Katz,

Eva Margalith,

Bela Winer

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.1.85

Subject(s) - semicarbazone , mutant , vaccinia , virus , virology , biology , chemistry , orthopoxvirus , poxviridae , microbiology and biotechnology , biochemistry , stereochemistry , gene , recombinant dna

gamma-Thiochromanone-4-thiosemicarbazone (TCT) inhibits the growth of vaccinia virus in BSCl cells by interfering with viral maturation. A mutant of the virus (TCT(R)) which is resistant to this drug was isolated. This mutant also exhibits resistance to another thiosemicarbazone related compound, isatin beta-thiosemicarbazone (IBT). There is a good correlation between the cross-resistance of the two mutants IBT(R) and TCT(R) to TCT and IBT, respectively, and the similar antipoxvirus activity of these two thiosemicarbazone-related compounds.

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