Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis | Zendy

Michele Danish | Zendy; Robert W. Schultz | Zendy; William J. Jusko | Zendy

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Pharmacokinetics of Gentamicin and Kanamycin During Hemodialysis

Author(s) -

Michele Danish,

Robert W. Schultz,

William J. Jusko

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.6.6.841

Subject(s) - pharmacokinetics , hemodialysis , kanamycin , gentamicin , clearance , medicine , antibiotics , aminoglycoside , pharmacology , regimen , creatinine , antibacterial agent , intensive care medicine , surgery , urology , microbiology and biotechnology , biology

The pharmacokinetics of gentamicin, kanamycin, and creatinine were studied in patients undergoing hemodialysis. After intravenous injection of single doses of the drugs, 50 to 60% of the doses of both antibiotics were cleared from the body during a 6-h period; this occurred almost entirely by the hemodialysis process. No correlation was found between the dialysance of the aminoglycosides and creatinine. The pharmacokinetic data were used to make dosage regimen recommendations for treatment of hemodialysis patients with these antibiotics.

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