Simple Assay for Clindamycin in the Presence of Aminoglycosides | Zendy

Frank R. Ervin | Zendy; Ward E. Bullock | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Simple Assay for Clindamycin in the Presence of Aminoglycosides

Author(s) -

Frank R. Ervin,

Ward E. Bullock

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.6.6.831

Subject(s) - clindamycin , aminoglycoside , bioassay , sarcina , antibiotics , antimicrobial , microbiology and biotechnology , chemistry , agar , chromatography , biology , bacteria , genetics

The presence of aminoglycoside antibiotics interferes with the determination of clindamycin levels by standard microbiological assay. A new bioassay method of quantitation of clindamycin in the presence of aminoglycosides is presented. This technique is based on the fact that incorporation of calcium chloride into assay agar blocks the antimicrobial activity of aminoglycosides against Sarcina lutea but allows the assay of as little as 0.31 mug of clindamycin per ml. The error of the system is less than 10%. This method is simple and adaptable to existing assay systems for clindamycin.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research