Open AccessEffect of R-Factor-Mediated Genes on Some Surface Properties of Escherichia coli
Author(s) -
Nigel A. C. Curtis,
M. H. Richmond
Publication year - 1974
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.6.6.666
Subject(s) - escherichia coli , plasmid , nalidixic acid , mutant , gene , microbiology and biotechnology , biology , enterobacteriaceae , strain (injury) , lysozyme , lysis , structural gene , genetics , anatomy
The plasmid RP1 was shown to contain a genetic region (theirp region) responsible for influencing the intrinsic resistance ofEscherichia coli to penicillins but not to cephalosporins. Mutants in which theirp genes are inactive were isolated. RP1 carrying functionalirp genes protectedE. coli AS19 against lysozyme lysis and also enhanced resistance to actinomycin D, to nalidixic acid, and to rifampin. This plasmid also phenotypically repaired the hypersensitivity to penicillins of strain AS19, and also that ofE. coli envA mutants. Similar regions were not detected on the plasmids R1 and R55.