Evaluation of the Efficacy of Minocycline Therapy for Staphylococcal Soft-Tissue Infection | Zendy

John Phair | Zendy; Rae E. Hartman | Zendy; Judith Carleton | Zendy

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Evaluation of the Efficacy of Minocycline Therapy for Staphylococcal Soft-Tissue Infection

Author(s) -

John Phair,

Rae E. Hartman,

Judith Carleton

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.6.5.551

Subject(s) - minocycline , staphylococcus aureus , tetracycline , microbiology and biotechnology , in vitro , soft tissue , antibiotics , micrococcaceae , medicine , staphylococcal infections , antibacterial agent , biology , surgery , bacteria , biochemistry , genetics

Ten patients with soft-tissue infections due to Staphylococcus aureus were treated with minocycline, a semisynthetic tetracycline with potent in vitro antistaphylococcal effects. Serum concentrations averaged three to five times the concentration of minocycline required to inhibit growth of S. aureus in vitro. Clearing of the infecting organism was slow (less than 50% of lesions were sterile on day 10 of therapy), but clinical improvement was noted in 8 of 10 patients.

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