Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea | Zendy

Ana Duanćić | Zendy; Nicholas J. Fiumara | Zendy; Susan Alpert | Zendy; Yhu-Hsiung Lee | Zendy; Philip Tarr | Zendy; Bernard Rosner | Zendy; William M. McCormack | Zendy

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Comparison of Spectinomycin Hydrochloride and Aqueous Procaine Penicillin G in the Treatment of Uncomplicated Gonorrhea

Author(s) -

Ana Duanćić,

Nicholas J. Fiumara,

Susan Alpert,

Yhu-Hsiung Lee,

Philip Tarr,

Bernard Rosner,

William M. McCormack

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.6.4.512

Subject(s) - spectinomycin , gonorrhea , penicillin , procaine , medicine , neisseria gonorrhoeae , antibiotics , pharmacology , microbiology and biotechnology , biology , immunology , human immunodeficiency virus (hiv)

Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).

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