Open AccessPost-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose
Author(s) -
Maurice W. Harmon,
Burton Janis,
Hilton B. Levy
Publication year - 1974
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.6.4.507
Subject(s) - rabies , interferon , rabies virus , titer , stimulation , chemistry , virology , microbiology and biotechnology , pharmacology , medicine , immunology , biology , virus
Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 μg each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.