Comparison of Enzymatic and Microbiological Gentamicin Assays | Zendy

Arnold L. Smith | Zendy; J. Allan Waitz | Zendy; David H. Smith | Zendy; Edwin M. Oden | Zendy; Barbara B. Emerson | Zendy

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Comparison of Enzymatic and Microbiological Gentamicin Assays

Author(s) -

Arnold L. Smith,

J. Allan Waitz,

David H. Smith,

Edwin M. Oden,

Barbara B. Emerson

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.6.3.316

Subject(s) - gentamicin , urine , correlation coefficient , dose , linear regression , antibiotics , linear correlation , confidence interval , medicine , chemistry , chromatography , pharmacology , mathematics , biochemistry , statistics

The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.

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