Open AccessNeuraminidase Inhibitor-Resistant and -Sensitive Influenza B Viruses Isolated from an Untreated Human Patient
Author(s) -
Aeron C. Hurt,
Pina Iannello,
Kim Jachno,
Naomi Komadina,
Alan Hampson,
Ian Barr,
Jennifer L. McKimm-Breschkin
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.5.1872-1874.2006
Subject(s) - neuraminidase , neuraminidase inhibitor , virology , microbiology and biotechnology , virus , biology , orthomyxoviridae , population , oseltamivir , influenzavirus b , influenza a virus , medicine , covid-19 , infectious disease (medical specialty) , disease , environmental health , pathology
An influenza B virus from an infant with no history of treatment or contact with neuraminidase inhibitors demonstrated a significant reduction in sensitivity to these drugs. Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was responsible for this reduction.