Open AccessRoles of Cellular Respiration, Cg CDR1 , and Cg CDR2 in Candida glabrata Resistance to Histatin 5
Author(s) -
Eva J. Helmerhorst,
Caterina Venuleo,
Dominique Sanglard,
Frank G. Oppenheim
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.3.1100-1103.2006
Subject(s) - candida glabrata , fluconazole , microbiology and biotechnology , biology , efflux , downregulation and upregulation , antifungal , biochemistry , gene
Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective againstCandida glabrata . Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance ofC. glabrata to histatin 5 is related to similar mechanisms.