Open AccessIn Vitro Activity of DX-619, a Novel Des-Fluoro(6) Quinolone, against a Panel of Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms
Author(s) -
Paul A. Wickman,
Ellen Smith Moland,
Jennifer Ann Black,
Kenneth S. Thomson
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.2.796-798.2006
Subject(s) - streptococcus pneumoniae , quinolone , mutant , in vitro , microbiology and biotechnology , streptococcaceae , biology , chemistry , antibiotics , gene , genetics
The in vitro activities of DX-619 and four other quinolones were compared againstStreptococcus pneumoniae mutants that contained a variety of alterations within the quinolone resistance-determining regions. DX-619 was the most potent quinolone and was least affected by the mutations.