Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes | Zendy

Klaudia Kosowska-Shick | Zendy; Catherine Clark | Zendy; Kim Credito | Zendy; Pamela McGhee | Zendy; Bonifacio Dewasse | Zendy; Tatiana Bogdanovich | Zendy; Peter C. Appelbaum | Zendy

Open Access

Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes

Author(s) -

Klaudia Kosowska-Shick,

Catherine Clark,

Kim Credito,

Pamela McGhee,

Bonifacio Dewasse,

Tatiana Bogdanovich,

Peter C. Appelbaum

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.50.2.765-769.2006

Subject(s) - staphylococcus aureus , streptococcus pyogenes , microbiology and biotechnology , biology , mutant , staphylococcus , bacteria , genetics , gene

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.

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