Open AccessEfficacy of Quinolones against Secondary Pneumococcal Pneumonia after Influenza Virus Infection in Mice
Author(s) -
Kozaburo Hayashi,
Shigenori Kadowaki,
Masaya Takei,
Hideyuki Fukuda
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.2.748-751.2006
Subject(s) - pneumonia , gatifloxacin , streptococcus pneumoniae , pneumococcal pneumonia , medicine , microbiology and biotechnology , virus , virology , bacterial pneumonia , influenza a virus , pneumococcal infections , immunology , antibiotics , biology , levofloxacin
We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.