Efficacy of Quinolones against Secondary Pneumococcal Pneumonia after Influenza Virus Infection in Mice | Zendy

Katsuhiko Hayashi | Zendy; Shin-etsu Kadowaki | Zendy; Masaya Takei | Zendy; Hideyuki Fukuda | Zendy

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Efficacy of Quinolones against Secondary Pneumococcal Pneumonia after Influenza Virus Infection in Mice

Author(s) -

Katsuhiko Hayashi,

Shin-etsu Kadowaki,

Masaya Takei,

Hideyuki Fukuda

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.50.2.748-751.2006

Subject(s) - pneumonia , gatifloxacin , streptococcus pneumoniae , pneumococcal pneumonia , medicine , microbiology and biotechnology , virus , virology , bacterial pneumonia , influenza a virus , pneumococcal infections , immunology , antibiotics , biology , levofloxacin

We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.

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