Open AccessDoxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice
Author(s) -
Masaki Fujita,
Qing Ye,
Hiroshi Okumura,
Eiji Harada,
Ichiro Inoshima,
Kazuyoshi Kuwano,
Yoichi Nakanishi
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.2.739-743.2006
Subject(s) - doxycycline , bleomycin , pulmonary fibrosis , fibrosis , medicine , gelatinase , pharmacology , immunology , pathology , matrix metalloproteinase , biology , chemotherapy , microbiology and biotechnology , antibiotics
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.