Antiviral Activity of 3-Methyleneoxindole | Zendy

V. Tuli | Zendy; H.S. Moyed | Zendy; Douglas Stevenson | Zendy; Irving Gordon | Zendy

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Antiviral Activity of 3-Methyleneoxindole

Author(s) -

V. Tuli,

H.S. Moyed,

Douglas Stevenson,

Irving Gordon

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.5.5.479

Subject(s) - sindbis virus , virology , interferon , mode of action , chemistry , viral replication , biology , virus , antiviral therapy , indole test , stereochemistry , biochemistry , rna , gene , chronic hepatitis

3-Methyleneoxindole (MO), an oxidation product of the plant auxin indole-3-acetic acid, can selectively inhibit the replication of herpes-, mengo-, polioviruses, and Sindbis virus. The antiviral action of MO, a sulfhydryl binding compound, is neutralized by 2-mercaptoethanol if the latter is added soon after exposure of infected cells to MO. If addition of 2-mercaptoethanol is delayed, the antiviral action of MO appears to be irreversible. Data are presented which indicate that the antiviral action of MO is not mediated by interferon.

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