Open AccessAntiviral Activity of 3-Methyleneoxindole
Author(s) -
V. Tuli,
H.S. Moyed,
Douglas Stevenson,
Irving Gordon
Publication year - 1974
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.5.5.479
Subject(s) - sindbis virus , virology , interferon , mode of action , chemistry , viral replication , biology , virus , antiviral therapy , indole test , stereochemistry , biochemistry , rna , gene , chronic hepatitis
3-Methyleneoxindole (MO), an oxidation product of the plant auxin indole-3-acetic acid, can selectively inhibit the replication of herpes-, mengo-, polioviruses, and Sindbis virus. The antiviral action of MO, a sulfhydryl binding compound, is neutralized by 2-mercaptoethanol if the latter is added soon after exposure of infected cells to MO. If addition of 2-mercaptoethanol is delayed, the antiviral action of MO appears to be irreversible. Data are presented which indicate that the antiviral action of MO is not mediated by interferon.