Open AccessPreparation of Succinyl Neocarzinostatin
Author(s) -
Hiroshi Maeda
Publication year - 1974
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.5.3.354
Subject(s) - neocarzinostatin , succinic anhydride , in vitro , chemistry , bacteria , antibiotics , microbiology and biotechnology , biochemistry , biology , organic chemistry , genetics , dna
All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis-N-succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.
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