Comparative Clinical Study of Tobramycin and Gentamicin | Zendy

Jean Klášterský | Zendy; Colette Hensgens | Zendy; Alain Henri | Zendy; D. Daneau | Zendy

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Comparative Clinical Study of Tobramycin and Gentamicin

Author(s) -

Jean Klášterský,

Colette Hensgens,

Alain Henri,

D. Daneau

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.5.2.133

Subject(s) - tobramycin , gentamicin , pseudomonas aeruginosa , medicine , antibiotics , aminoglycoside , microbiology and biotechnology , proteus infections , meningitis , biology , surgery , bacteria , proteus mirabilis , genetics

Gentamicin and tobramycin have been compared in vitro and as single-drug therapy in patients with a serious infection caused by gram-negative rods. In vitro, a slight advantage of tobramycin over gentamicin has been found against Pseudomonas aeruginosa. Cross-resistance between gentamicin and tobramycin has been observed for gentamicin-resistant strains of P. aeruginosa and Providence but was not always present. The clinical effectiveness of gentamicin and tobramycin was similar: 14 (45.1%) out of the 31 patients in each series responded favorably. The clinical results were much better in urinary tract infections (66% of favorable responses) than in wound infections, pulmonary infections, septicemia, and meningitis (26% of favorable responses). The frequency of adverse reactions encountered in the present series was similar for both drugs.

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