Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria | Zendy

Daniel M. Musher | Zendy; Corando Saenz | Zendy; Donald P. Griffith | Zendy

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Interaction Between Acetohydroxamic Acid and 12 Antibiotics Against 14 Gram-Negative Pathogenic Bacteria

Author(s) -

Daniel M. Musher,

Corando Saenz,

Donald P. Griffith

Publication year - 1974

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.5.2.106

Subject(s) - acetohydroxamic acid , antibiotics , microbiology and biotechnology , bacteria , urease , kanamycin , gram negative bacteria , antagonism , nalidixic acid , biology , chemistry , biochemistry , enzyme , ampicillin , escherichia coli , genetics , receptor , gene

Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.

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