Open AccessBiological Assay of Streptonigrin (NSC 45383) in Body Fluids and Tissues of Mice
Author(s) -
Robert F. Pittillo,
Carolyn Woolley
Publication year - 1974
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.5.1.82
Subject(s) - antibiotics , biological fluids , pharmacology , drug , chemistry , microbiology and biotechnology , biology , chromatography
Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement successful clinical application of this drug.
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