Open AccessEffect of Antibiotic Treatment on Growth of and Toxin Production by Clostridium difficile in the Cecal Contents of Mice
Author(s) -
Nicole J. Pultz,
Curtis J. Donskey
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.8.3529-3532.2005
Subject(s) - microbiology and biotechnology , antibiotics , clindamycin , clostridium difficile , piperacillin , cefepime , aztreonam , levofloxacin , antibiotic associated diarrhea , clostridium perfringens , piperacillin/tazobactam , clostridium , anaerobic bacteria , biology , clostridium difficile toxin a , clostridiaceae , toxin , bacteria , antibiotic resistance , imipenem , genetics , pseudomonas aeruginosa
In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.