Open AccessPrevention of the Cryptic Epitope SLAYGLR within Osteopontin Does Not Influence Susceptibility to Candida albicans Infection
Author(s) -
Ikuko Sato,
Norikazu Yamamoto,
Harumi Yamazaki,
Seiji Hashimoto,
Motohiro Hino,
Fumihiko Sakai,
Akihiko Fujie
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.7.3053-3055.2005
Subject(s) - candida albicans , osteopontin , epitope , antibody , microbiology and biotechnology , biology , immunology , tumor necrosis factor alpha , corpus albicans , virology
The effect of an antiosteopontin antibody (M5 Ab) reacting with the SLAYGLR sequence within osteopontin on the host susceptibility to infection was investigated in a murine model of disseminated candidiasis. The treatment with anti-tumor necrosis factor alpha antibody enhanced fungal infection, while the treatment with M5 Ab did not affect the infection.