Open AccessIn Vitro Activity of an Oral Streptogramin Antimicrobial, XRP2868, against Gram-Positive Bacteria
Author(s) -
George M. Eliopoulos,
Mary Jane Ferraro,
Christine Wennersten,
Robert C. Moellering
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.7.3034-3039.2005
Subject(s) - quinupristin , enterococcus faecium , microbiology and biotechnology , dalfopristin , virginiamycin , antimicrobial , enterococcus , gram positive bacteria , biology , staphylococcus aureus , antibiotics , bacteria , antibacterial agent , potency , in vitro , vancomycin , biochemistry , genetics
The comparative in vitro potency of XRP2868, a new oral semisynthetic streptogramin antibiotic, was evaluated against gram-positive bacteria. XRP2868 inhibited all staphylococci at < or = 1 microg/ml and all non-pneumococcal streptococci at < or = 0.25 microg/ml and was fourfold more potent than quinupristin-dalfopristin against Staphylococcus aureus and Enterococcus faecium.