Open AccessIn Vitro Activity and Killing Effect of Citropin 1.1 against Gram-Positive Pathogens Causing Skin and Soft Tissue Infections
Author(s) -
Andrea Giacometti,
Oscar Cirioni,
Wojciech Kamysz,
Carmela Silvestri,
Maria Simona Del Prete,
Alberto Licci,
Giuseppina D’Amato,
Jerzy Łukasiak,
Giorgio Scalise
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.6.2507-2509.2005
Subject(s) - microbiology and biotechnology , gram , in vitro , checkerboard , clarithromycin , biology , antibacterial agent , gram positive bacteria , minimum inhibitory concentration , antibiotics , doxycycline , bacteria , biochemistry , genetics
The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.