Open AccessIn Vitro and In Vivo Activities of DA-7867, a New Oxazolidinone, against Aerobic Gram-Positive Bacteria
Author(s) -
Eunju Yoon,
Young Tak Jo,
Sun Jin Choi,
Tae Ho Lee,
Jinsu Rhee,
Moohi Yoo,
Mi Ja Shim,
EungChil Choi
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.6.2498-2500.2005
Subject(s) - linezolid , microbiology and biotechnology , staphylococcus aureus , in vivo , streptococcus pneumoniae , in vitro , penicillin , vancomycin , antibiotics , bacteria , gram positive bacteria , biology , enterococcus , gram , antibacterial agent , biochemistry , genetics
In vitro and in vivo activities of DA-7867 were assessed against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin-resistant Streptococcus pneumoniae. All isolates were inhibited by DA-7867 at <or=0.78 microg/ml, a four-times-lower concentration than that of inhibition by linezolid. For murine infection models, DA-7867 also exhibited greater efficacy than linezolid against all isolates tested.