Open AccessDifferences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene ( cyp51A ) of Aspergillus fumigatus
Author(s) -
Guillermo GarcíaEffrón,
Emilia Mellado,
Alicia GómezLópez,
Laura Alcázar-Fuoli,
Manuel CuencaEstrella,
Juan Luis Rodríguez-Tudela
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.5.2119-2121.2005
Subject(s) - azole , aspergillus fumigatus , itraconazole , voriconazole , microbiology and biotechnology , gene knockout , biology , posaconazole , gene , sterol , antifungal , genetics , biochemistry , cholesterol
The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.