Open AccessPharmacokinetic Profile of Tigecycline in Serum and Skin Blister Fluid of Healthy Subjects after Multiple Intravenous Administrations
Author(s) -
Heather K. Sun,
Christine T. Ong,
Ambreen Umer,
Dawn Harper,
Steven Troy,
Charles H. Nightingale,
David P. Nicolau
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.4.1629-1632.2005
Subject(s) - tigecycline , pharmacokinetics , medicine , penetration (warfare) , serum concentration , pharmacology , anesthesia , antibiotics , microbiology and biotechnology , biology , operations research , engineering
The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with a mean penetration rate of 74%.