Open AccessAntibiotic Tolerance Induced by Lactoferrin in Clinical Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
Author(s) -
María del Carmen Marca Andrés,
Mónica Viejo-Díaz,
Francisco A. Perez,
José F. Fierro
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.4.1613-1616.2005
Subject(s) - pseudomonas aeruginosa , tobramycin , cystic fibrosis , lactoferrin , antibiotics , microbiology and biotechnology , biology , multidrug tolerance , bacteria , gentamicin , biofilm , biochemistry , genetics
Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (< or = 6-fold) than other clinical strains.