Open AccessComparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease
Author(s) -
Milagros Corrales,
Rubén Marino Cardozo,
María Asunción Segura,
Julio A. Urbina,
Miguel Á. Basombrío
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.4.1556-1560.2005
Subject(s) - benznidazole , trypanosoma cruzi , chagas disease , ergosterol , pharmacology , trypanocidal agent , disease , biology , medicine , immunology , biochemistry , parasite hosting , world wide web , computer science
We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.