Open AccessCombination Therapy with Amphotericin B Lipid Complex and Caspofungin Acetate of Disseminated Zygomycosis in Diabetic Ketoacidotic Mice
Author(s) -
Brad Spellberg,
Yue Fu,
John E. Edwards,
Ashraf S. Ibrahim
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.2.830-832.2005
Subject(s) - caspofungin , zygomycosis , amphotericin b , combination therapy , rhizopus oryzae , medicine , pharmacology , mycosis , salvage therapy , chemotherapy , immunology , chemistry , antifungal , biochemistry , dermatology , fermentation
We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae. Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.
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