Open AccessThe Biocide Triclosan Selects Stenotrophomonas maltophilia Mutants That Overproduce the SmeDEF Multidrug Efflux Pump
Author(s) -
Patricia Sánchez,
Eduardo Moreno,
José Luis Martínez
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.2.781-782.2005
Subject(s) - triclosan , stenotrophomonas maltophilia , efflux , microbiology and biotechnology , biocide , antibiotics , multiple drug resistance , mutant , bacteria , biology , stenotrophomonas , chemistry , pseudomonas aeruginosa , medicine , pseudomonas , biochemistry , genetics , gene , organic chemistry , pathology
The possibility that triclosan selects Stenotrophomonas maltophilia mutants overexpressing the multidrug resistance pump SmeDEF is analyzed. Five out of 12 triclosan-selected mutants were less susceptible to antibiotics than the wild-type strain and overproduced SmeDEF. Results are discussed in relation to current debates on the potential selection of antibiotic-resistant bacteria by household biocides.