Caspofungin and Liposomal Amphotericin B Therapy of Experimental Murine Scedosporiosis | Zendy

Rosie Bocanegra | Zendy; Laura K. Najvar | Zendy; Steve Hernandez | Zendy; Dora I. McCarthy | Zendy; John R. Graybill | Zendy

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Caspofungin and Liposomal Amphotericin B Therapy of Experimental Murine Scedosporiosis

Author(s) -

Rosie Bocanegra,

Laura K. Najvar,

Steve Hernandez,

Dora I. McCarthy,

John R. Graybill

Publication year - 2005

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.49.12.5139-5141.2005

Subject(s) - caspofungin , amphotericin b , pharmacology , combination therapy , medicine , antifungal , microbiology and biotechnology , biology

Immunosuppressed mice were infected intravenously with conidia ofScedosporium prolificans . Treatment was begun 1 day later with liposomal amphotericin B, caspofungin, or both drugs initiated concurrently. Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone.

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