Open AccessCaspofungin and Liposomal Amphotericin B Therapy of Experimental Murine Scedosporiosis
Author(s) -
Rosie Bocanegra,
Laura K. Najvar,
Steve Hernandez,
Dora I. McCarthy,
John R. Graybill
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.12.5139-5141.2005
Subject(s) - caspofungin , amphotericin b , pharmacology , combination therapy , medicine , antifungal , microbiology and biotechnology , biology
Immunosuppressed mice were infected intravenously with conidia ofScedosporium prolificans . Treatment was begun 1 day later with liposomal amphotericin B, caspofungin, or both drugs initiated concurrently. Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone.