Open AccessPitfalls in Estimating Piperaquine Elimination
Author(s) -
Joel Tärning,
Niklas Lindegårdh,
Anna Annerberg,
Thida Singtoroj,
Nicholas Day,
Michael Ashton,
Nicholas J. White
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.12.5127-5128.2005
Subject(s) - piperaquine , pharmacology , volunteer , pharmacokinetics , medicine , biology , malaria , immunology , plasmodium falciparum , artemisinin , agronomy
By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in characterizing the disposition of slowly eliminated antimalarial drugs.