Open AccessTLA-2, a Novel Ambler Class A Expanded-Spectrum β-Lactamase
Author(s) -
Delphine Girlich,
Laurent Poirel,
Andreas Schlüter,
Patrice Nordmann
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.49.11.4767-4770.2005
Subject(s) - microbiology and biotechnology , antibacterial agent , broad spectrum , class (philosophy) , biology , antibiotics , chemistry , computer science , artificial intelligence , combinatorial chemistry
β-Lactamase TLA-2 is encoded by a 47-kb plasmid isolated from an unidentified bacterial strain from a wastewater treatment plant. TLA-2 is an Ambler class A β-lactamase that shares 52% amino acid identity with CGA-1 fromChryseobacterium gleum and 51% with TLA-1 fromEscherichia coli . The enzyme hydrolyzes mostly cephalosporins.