Open AccessDistribution of Amphotericin B-Arabinogalactan Conjugate in Mouse Tissue and Its Therapeutic Efficacy against Murine Aspergillosis
Author(s) -
Rama Falk,
Jacob Grunwald,
Am Hoffman,
Abraham J. Domb,
Itzhack Polacheck
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.9.3606-3609.2004
Subject(s) - amphotericin b , conjugate , aspergillosis , arabinogalactan , pharmacokinetics , distribution (mathematics) , pharmacology , amphotericin b deoxycholate , drug , microbiology and biotechnology , chemistry , biology , medicine , immunology , polysaccharide , antifungal , biochemistry , mathematical analysis , mathematics , caspofungin
The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.