Open AccessCMY-13, a Novel Inducible Cephalosporinase Encoded by anEscherichia coliPlasmid
Author(s) -
Vivì Miriagou,
L. S. Tzouvelekis,
Laura Villa,
Evangelia Lebessi,
A. Vatopoulos,
Alessandra Carattoli,
E. Tzelepi
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.8.3172-3174.2004
Subject(s) - citrobacter freundii , escherichia coli , plasmid , enterobacteriaceae , biology , microbiology and biotechnology , citrobacter , genetics , gene
An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments.