Open AccessPharmacokinetics of Intravenous Itraconazole in Stable Hemodialysis Patients
Author(s) -
John Mohr,
Kevin W. Finkel,
John H. Rex,
José R. Rodríguez,
G Leitz,
Luis Ostrosky-Zeichner
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.8.3151-3153.2004
Subject(s) - pharmacokinetics , itraconazole , hemodialysis , dialysis , medicine , pharmacology , clearance , area under the curve , half life , urology , antifungal , dermatology
The pharmacokinetics of intravenous itraconazole (ITC) was studied in dialysis patients. Dialysis had no effect on the half-life and clearance of ITC or OH-ITC. However, dialysis allowed the clearance of hydroxypropyl-beta-cyclodextrin (HP-beta-CD). The area under the concentration-time curve from time zero to infinity (AUC(0- infinity)) for HP-beta-CD administered before dialysis was lower than the AUC(0- infinity) when it was administered after dialysis (P < 0.01). Administration of ITC intravenously just prior to hemodialysis appears to produce adequate systemic exposures of ITC and OH-ITC while allowing dialysis clearance of HP-beta-CD. Studies of multiple administrations are warranted.