Open AccessEradication of Streptococcus pneumoniae in the Nasopharyngeal Flora of Children with Acute Otitis Media after Amoxicillin-Clavulanate Therapy
Author(s) -
Itzhak Brook,
Alan E. Gober
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.4.1419-1421.2004
Subject(s) - streptococcus pneumoniae , amoxicillin , otitis , acute otitis media , medicine , streptococcaceae , streptococcus , microbiology and biotechnology , clavulanic acid , moraxella catarrhalis , antibacterial agent , pneumococcal infections , gastroenterology , immunology , antibiotics , biology , surgery , bacteria , genetics
Nasopharyngeal cultures were obtained from 60 children with acute otitis media before and after treatment with either 45 or 90 mg of amoxicillin (given as amoxicillin-clavulanate) per kg of body weight per day for 10 days. The number of Streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (P = 0.0261) in the 90-mg/kg group.