Open AccessInhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains
Author(s) -
Jacqueline Chevalier,
Jérôme Bredin,
Abdallah Mahamoud,
Monique Malléa,
Jacques Barbe,
JeanMarie Pagès
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.3.1043-1046.2004
Subject(s) - enterobacter aerogenes , efflux , klebsiella pneumoniae , microbiology and biotechnology , antibiotics , chloramphenicol , multiple drug resistance , biology , klebsiella , enterobacter , drug resistance , escherichia coli , biochemistry , gene
In Enterobacter aerogenes and Klebsiella pneumoniae, efflux provides efficient extrusion of antibiotics and contributes to the multidrug resistance phenotype. One of the alkoxyquinoline derivatives studied here, 2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline, restores noticeable drug susceptibility to resistant clinical strains. Analyses of energy-dependent chloramphenicol efflux indicate that this compound inhibits the efflux pump mechanism and improves the activity of structurally unrelated antibiotics on multidrug-resistant E. aerogenes and K. pneumoniae isolates.