Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates | Zendy

Raquel Eve Barbolla | Zendy; Mariana Catalano | Zendy; Betina Orman | Zendy; Ángela Famiglietti | Zendy; Carlos Vay | Zendy; Jorgelina Smayevsky | Zendy; Daniela Centrón | Zendy; Silvia A. Piñeiro | Zendy

Open Access

Class 1 Integrons Increase Trimethoprim-Sulfamethoxazole MICs against Epidemiologically Unrelated Stenotrophomonas maltophilia Isolates

Author(s) -

Raquel Eve Barbolla,

Mariana Catalano,

Betina Orman,

Ángela Famiglietti,

Carlos Vay,

Jorgelina Smayevsky,

Daniela Centrón,

Silvia A. Piñeiro

Publication year - 2004

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.48.2.666-669.2004

Subject(s) - stenotrophomonas maltophilia , sulfamethoxazole , trimethoprim , microbiology and biotechnology , biology , pseudomonadaceae , gram negative bacterial infections , stenotrophomonas , antibacterial agent , pseudomonas , virology , pseudomonas aeruginosa , antibiotics , bacteria , genetics

Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.

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