Open AccessEmergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-β-Lactamase Encoded by a Conjugative Plasmid
Author(s) -
Francesco Luzzaro,
Jean Denis Docquier,
Céline Coli,
Andrea Endimiani,
Giuseppe Lombardi,
Gianfranco Amicosante,
Gian María Rossolini,
Antonio Toniolo
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.2.648-650.2004
Subject(s) - enterobacter cloacae , klebsiella pneumoniae , microbiology and biotechnology , plasmid , enterobacteriaceae , biology , klebsiella , carbapenem , enterobacter , antibiotics , escherichia coli , gene , genetics
Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-beta-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.