Open AccessSafety and Efficacy of Antimicrobial Peptides against Naturally Acquired Leishmaniasis
Author(s) -
Jordi Alberola,
Alejandra Rodríguez,
Olga Francino,
Xavier Roura,
Luís Rivas,
David Andreu
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.2.641-643.2004
Subject(s) - antimicrobial , leishmaniasis , antimicrobial peptides , medicine , anti infective agents , biology , microbiology and biotechnology , immunology , pharmacology
Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.