Open AccessVanE-Type Vancomycin-Resistant Enterococcus faecalis Clinical Isolates from Australia
Author(s) -
Lorena Abadía-Patiño,
Keryn Christiansen,
Jan M. Bell,
Patrice Courvalin,
Bruno Périchon
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.12.4882-4885.2004
Subject(s) - enterococcus faecalis , operon , gene , enterococcus , microbiology and biotechnology , biology , transcription (linguistics) , start codon , genetics , antibiotics , messenger rna , escherichia coli , linguistics , philosophy
Three distinct Enterococcus faecalis VanE-type isolates-BM4574, BM4575, and BM4576-obtained in Australia were studied. Expression of the resistance genes was constitutive in BM4575, probably due to a 2-bp deletion into the vanSE gene, and inducible in BM4574 and BM4576. Transcription analysis of the vanE operons suggested that the five genes were cotranscribed from an initiation site located 25 bp upstream from the ATG start codon of vanE.