Open AccessEffect of Parenteral Fluoroquinolone Administration on Persistence of Vancomycin-Resistant Enterococcus faecium in the Mouse Gastrointestinal Tract
Author(s) -
Curtis J. Donskey,
Marion S. Helfand,
Nicole J. Pultz,
Louis B. Rice
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.1.326-328.2004
Subject(s) - gatifloxacin , levofloxacin , ciprofloxacin , enterococcus faecium , vancomycin , moxifloxacin , antibiotics , antibacterial agent , persistence (discontinuity) , ofloxacin , gastrointestinal tract , medicine , enterococcus , colonization , microbiology and biotechnology , biology , bacteria , staphylococcus aureus , geotechnical engineering , genetics , engineering
We examined the effect of subcutaneous fluoroquinolone antibiotic administration on persistence and density of vancomycin-resistant Enterococcus faecium stool colonization in mice. Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion.