Open AccessEfficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis
Author(s) -
Michael W. Dunne,
Chandra Mohini Khurana,
Adriano Arguedas Mohs,
Adib Rodriguez,
Antonio Arrieta,
Samuel E. McLinn,
Judy A. Krogstad,
Mark M. Blatter,
Richard H. Schwartz,
Sergio L. Vargas,
Paz Emparanza,
P. Fernández,
W. Manford Gooch,
Mary M. Aspin,
John K. Podgore,
Irmeli Roine,
Jeffrey L. Blumer,
Garth D. Ehrlich,
Jean Chow
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.8.2663-2665.2003
Subject(s) - medicine , azithromycin , streptococcus pneumoniae , haemophilus influenzae , regimen , cure rate , otitis , antibiotics , amoxicillin , acute otitis media , surgery , microbiology and biotechnology , biology
Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.