Open AccessTissue Penetration by Ertapenem, a Parenteral Carbapenem Administered Once Daily, in Suction-Induced Skin Blister Fluid in Healthy Young Volunteers
Author(s) -
Tine Laethem,
Inge De Lepeleire,
Jacqueline B. McCrea,
J. Zhang,
Anup Majumdar,
Donald G. Musson,
D. W. O. Rogers,
S. Li,
Michel Guillaume,
Anne Parneix-Spake,
Paul Deutsch
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.4.1439-1442.2003
Subject(s) - suction blister , blisters , ertapenem , penetration (warfare) , medicine , pharmacokinetics , suction , surgery , antibiotics , microbiology and biotechnology , biology , immunology , mechanical engineering , antibiotic resistance , imipenem , operations research , engineering
The penetration of 1 g of intravenous ertapenem once daily for 3 days in suction-induced skin blisters was evaluated. Ten forearm blisters were formed (n = 12) 12 h prior to the last dose. Concentrations of ertapenem in blister fluid exceeded 4 micro g/ml (the MIC at which 90% of the isolates tested are eliminated) for the entire dosing interval. The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration.