Open AccessMolecular Characterization and Antimicrobial Susceptibility of Fluoroquinolone-Resistant or -Susceptible Streptococcus pneumoniae from Hong Kong
Author(s) -
Ian Morrissey,
David J. Farrell,
S. Bakker,
Sylvie Buckridge,
D. Felmingham
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.4.1433-1435.2003
Subject(s) - telithromycin , streptococcus pneumoniae , microbiology and biotechnology , quinupristin , dalfopristin , ketolide , biology , antibacterial agent , antimicrobial , linezolid , moxifloxacin , clone (java method) , antibiotics , virology , bacteria , staphylococcus aureus , genetics , vancomycin , dna
Fluoroquinolone resistance in Streptococcus pneumoniae isolated from Hong Kong as part of Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin 1999/2000 was found to be due to the spread of the Spain(23F)-1 clone (mainly a Spain(23F)-1-14 variant). All the isolates were multidrug resistant but were susceptible to quinupristin-dalfopristin, linezolid, and telithromycin. The Spain(23F)-1 clone also occurred among antimicrobial-susceptible isolates, which suggests that the primary source of this clone may have been Asia rather than Iberia.