Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice | Zendy

Anne J. Lenaerts | Zendy; Veronica Gruppo | Zendy; Jason V. Brooks | Zendy; Ian M. Orme | Zendy

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Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice

Author(s) -

Anne J. Lenaerts,

Veronica Gruppo,

Jason V. Brooks,

Ian M. Orme

Publication year - 2003

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.47.2.783-785.2003

Subject(s) - in vivo , tuberculosis , interferon gamma , pharmacology , gamma interferon , virology , biology , medicine , immunology , cytokine , genetics , pathology

We have developed a rapid new in vivo method for screening experimental drugs for their activity against Mycobacterium tuberculosis by using the gamma interferon gene-disrupted (GKO) C57BL/6 mouse. Due to the rapid growth of the infection, statistical differences indicating positive efficacy of active compounds can be seen after only 8 days of treatment. To validate this model, several fluoroquinolones, including ciprofloxacin, levofloxacin, moxifloxacin, and gatifloxacin, were tested in parallel.

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