Open AccessIn Vitro Activity of Recombinant Lysostaphin against Staphylococcus aureus Isolates from Anterior Nares and Blood
Author(s) -
Christof von Eiff,
John F. KokaiKun,
Karsten Becker,
Georg Peters
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.11.3613-3615.2003
Subject(s) - lysostaphin , staphylococcus aureus , microbiology and biotechnology , recombinant dna , in vitro , micrococcaceae , biology , bacteria , anterior nares , methicillin resistant staphylococcus aureus , biochemistry , gene , genetics
The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.