Open AccessPenetration of Dihydroartemisinin into Cerebrospinal Fluid after Administration of Intravenous Artesunate in Severe Falciparum Malaria
Author(s) -
Timothy M. E. Davis,
Trần Quang Bình,
Kenneth F. Ilett,
Kevin T. Batty,
Hoang Lan Phuöng,
Gregory M. Chiswell,
Vu Duong Bich Phuong,
Cindy Agus
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.1.368-370.2003
Subject(s) - artesunate , dihydroartemisinin , medicine , cerebrospinal fluid , convalescence , dosing , plasmodium falciparum , malaria , cerebral malaria , pentoxifylline , anesthesia , pharmacokinetics , pharmacology , surgery , artemisinin , immunology
Penetration of cerebrospinal fluid (CSF) by artesunate and DHA was assessed in six adults with cerebral or severe malaria. Lumbar punctures were performed on admission and during convalescence, at 15 min (patient 1), 30 min (patient 2), 45 min (patient 3), 60 min (patient 4), 90 min (patient 5), and 120 min (patient 6) after intravenous administration of 120 mg of artesunate. No artesunate was detectable in CSF. In both studies, DHA levels in CSF increased with time while dihydroartemisinin levels in plasma fell. Dihydroartemisinin might accumulate in CSF during frequent artesunate dosing.